Jiufeng Li

This study identifies macrophage Tie2 signaling as critical for TMEM doorway-mediated vascular permeability and metastatic dissemination in breast cancer.

This study identifies MenaINV as essential for breast cancer stem cell extravasation but not survival, revealing distinct pathways for metastatic dominance.

This study shows that Mena promotes KRAS-driven pancreatic tumor growth and metastasis by enhancing oncogenic signaling pathways.

This study identifies TMEM doorways as a mechanism for metastasis in PDAC, showing Tie2 macrophages facilitate intravasation and that targeting Tie2 improves survival in mouse models.