Yiqiao Zheng

This study examines retinal and vascular abnormalities in mouse models with CRX homeodomain mutations, finding disrupted photoreceptor differentiation and retinal rosettes that affect inner neuron localization and vasculature.

This study investigates how mutations in the CRX gene affect cooperative dimerization, leading to developmental defects in photoreceptors and retinal disease.

The paper examines how different pathogenic variants in the CRX gene affect cis-regulatory elements in photoreceptors, showing overlapping enhancer effects and distinct silencer impacts.

The paper creates a comprehensive human retina cell atlas using single-cell multi-omics data, revealing over 110 cell types and their gene regulatory networks, and enables fine-mapping of GWAS and eQTL variants.