Yan Zhang

This study shows FLASH radiotherapy promotes intestinal regeneration by preserving stem cells, enhancing WNT4 signaling, and reducing T-cell inflammation in mice.

This paper introduces SpliceAI2, a deep learning model that improves identification and quantification of splice-altering variants and their effects on transcripts and disease.

The paper introduces CIMA, a multi-omics atlas of human immune cells, identifying regulatory mechanisms and genetic associations across sex, age, and genetic factors.

This study identifies FBXO24's role in regulating mRNA alternative splicing and MIWI degradation, which is critical for sperm formation and piRNA production during spermiogenesis.

The paper presents the genome of Chinese fir, revealing evolutionary insights into gymnosperms and seed plant origins through phylogenomic and genomic analyses.

This study shows that atmospheric particulate matter worsens CNS demyelination by activating TLR-4/NF-κB signaling in microglia, leading to neuroinflammation and myelin injury.

HBP is a pipeline for analyzing Hi-C data to infer 3D genome structure and chromatin interactions, with confidence estimation and integration capabilities for other datasets.