Mingliang Zhang

This study shows that loss of PKP2 in cardiomyocytes induces pro-inflammatory senescence in non-myocytes and premature cardiac aging, linking desmosomal arrhythmogenic cardiomyopathy to cellular senescence and aging mechanisms.

The paper quantifies how taxonomic identity influences nitrogen cycling functions across bacterial genomes, revealing hierarchical constraints and ecological strategies.

This study identifies O-GlcNAcylation as a driver of remyelination, with Tet3 as a key downstream effector that modulates demethylation and myelin gene expression.