Kaitlyn S. Armijo

The paper shows that reduced mitochondrial respiratory capacity in myeloid cells during Mtb infection impairs immune function and Mtb control, with similar findings in human data.

This study identifies Rv1075c as a Mycobacterium tuberculosis nucleomodulin that interacts with the SET1 histone methyltransferase complex, modulating host inflammation and lipid metabolism to promote bacterial persistence.