Denis A. Mogilenko

The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.

The paper shows that reduced mitochondrial respiratory capacity in myeloid cells during Mtb infection impairs immune function and Mtb control, with similar findings in human data.

This study shows that inflammaging in aged tissues drives the development of age-associated CD8+ T cells through adipose tissue niches.

This study shows calorie restriction delays type 1 diabetes onset in NOD mice by enhancing glucose homeostasis and promoting a pro-tolerogenic islet microenvironment through increased PD-L1 expression.

This study shows that loss of the transferrin receptor (CD71) in Treg cells leads to tissue-specific inflammation and autoimmunity, highlighting the role of CD71-iron metabolism in Treg stability and function.

This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.