Vighnesh Ghatpande

Ribo-ITP identifies thousands of translons from low-input samples, revealing their regulatory roles and impact on cell growth.

The paper identifies four stages of forelimb initiation in mouse embryos using scRNA-seq and other sequencing methods, revealing TBX5-target genes involved in limb development.

The paper analyzes ribosome profiling data to show translation efficiency covariation (TEC) is conserved across human and mouse cells, revealing gene functions not evident from RNA or protein co-expression.

The paper measures mRNA translation in C. elegans embryos and identifies stage-specific translational regulation and the role of OMA-1 in repressing and promoting translation of target mRNAs.

This study investigates how loss of SCN1B affects neuronal function in the hippocampus of Scn1b knockout mice, revealing altered intrinsic excitability, synaptic properties, and information processing.

This paper develops Ribo-ITP to measure ribosome occupancy in single cells during early mouse development, revealing differential translation efficiency and allele-specific ribosome engagement.