Shilpa J Rao

The paper identifies a cytoplasmic surveillance pathway that detects and degrades faulty ribosomes during biogenesis but allows defective ribosomes to escape into translation if they bypass the pathway.

The paper analyzes ribosome profiling data to show translation efficiency covariation (TEC) is conserved across human and mouse cells, revealing gene functions not evident from RNA or protein co-expression.

The paper integrates multiplexed assays to identify cis-regulatory variants affecting COMT gene expression across multiple layers.

The paper shows Reh1 remains on 60S subunits during early translation elongation and is displaced by the growing peptide chain.

This paper develops Ribo-ITP to measure ribosome occupancy in single cells during early mouse development, revealing differential translation efficiency and allele-specific ribosome engagement.

The paper identifies genes with 5' terminal oligopyrimidine tracts that escape suppression by SARS-CoV-2 NSP1 through RNA-Seq and ribosome profiling, revealing a role for LARP1 in their preferential translation.