Author

Xuxu Gou

University of California, San FranciscoORCID 0000-0003-2318-778XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alan AshworthiD· 2 shared Morgan E. DiolaitiiD· 2 shared William F. DeGradoiD· 2 shared A. Katherine HatstatiD· 1 shared Dimitrios GazgalisiD· 1 shared Hyunil JoiD· 1 shared Hyunjun YangiD· 1 shared Ian J. BakanasiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Alan AshworthORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 7, 2026

De novo design of a protein fold for small-molecule binding through aromatic π stacking

Stephanie T. Ouchida, Maggie Horst, Xuxu Gou…·William F. DeGrado

This paper designs a de novo protein fold that binds doxorubicin with high affinity through aromatic π-stacking, revealing a new 5-helix globular fold.

DOI 10.64898/2026.08.06.743053

protein structuredeep learning

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BiophysicsSciencePeer-reviewedApr 4, 2024

De novo design of drug-binding proteins with predictable binding energy and specificity

Lei Lü, Xuxu Gou, Sophia K. Tan…·William F. DeGrado

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

78 citationstop 1%

protein structuredeep learning

𝕏 PostBluesky