Ian J. Bakanas

This paper designs a de novo protein fold that binds doxorubicin with high affinity through aromatic π-stacking, revealing a new 5-helix globular fold.

This study shows how a designed generalist binding protein can evolve into specific functions like a fluorophore binder and an efficient enzyme through weak, promiscuous interactions.

This paper designs a protein to bind naphthalenediimides and evaluates its ability to generate reactive species for proximity labeling.