Author

Maggie Horst

University of California SystemORCID 0000-0002-9794-5355Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

William F. DeGradoiD· 2 shared A. Katherine HatstatiD· 1 shared Alan AshworthiD· 1 shared Gessica M. Adornato· 1 shared Ian J. BakanasiD· 1 shared Kai-Peng HouiD· 1 shared Lee SchnaideriD· 1 shared Morgan E. DiolaitiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

William F. DeGradoORCID

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2 papers

Recent·Most cited

De novo design of a protein fold for small-molecule binding through aromatic π stacking

Stephanie T. Ouchida, Maggie Horst, Xuxu Gou, Ian J. Bakanas, A. Katherine Hatstat, Lee Schnaider, Morgan E. Diolaiti, Alan Ashworth, William F. DeGrado

This paper designs a de novo protein fold that binds doxorubicin with high affinity through aromatic π-stacking, revealing a new 5-helix globular fold.

bioRxiv · Aug 7, 2026 · PreprintBiochemistry

De Novo Design, Directed Evolution and Computational Study of Heme-Binding Helical Bundle Protein Catalysts for Biocatalytic Enantioselective Ge-H Insertion

Wei Huang, Gessica M. Adornato, Maggie Horst, Turki M. Alturaifi, Kai-Peng Hou, Peng Liu, William F. DeGrado, Yang Yang

This paper designs and evolves de novo helical bundle proteins to catalyze enantioselective Ge-H insertion, showing improved efficiency and selectivity through computational analysis and directed evolution.

Journal of the American Chemical Society · Oct 22, 2025Peer-reviewedBiochemistry