Hyunil Jo

Interplay of stability and dynamics in the optimization of a highly proficient de novo enzyme

This study identifies features contributing to catalytic efficiency in a de novo enzyme through computational design and directed evolution, showing how stability and dynamics interplay in enzyme optimization.

De novo design of ligand binding proteins using large language models alone

This paper demonstrates that large language models can generate de novo protein sequences that bind specific ligands without copying existing sequences, with a 25% hit rate in experimental validation.

Distinct tau filament folds in familial frontotemporal dementia due to the MAPT S305I mutation

This study identifies distinct tau filament structures in FTLD-tau caused by the MAPT S305I mutation, revealing a unique 4-layer architecture and potential RNA-like polyanion binding.

Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes

The paper develops a method to determine sequence-dependent propensities for membrane protein insertion states using glycosylation patterns and UMAP analysis.

IL-13 and IL-17A Activate β1 Integrin through an NF-κB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle

This paper shows IL-13 and IL-17A activate β1 integrins through an NF-κB/Rho kinase/PIP5K1γ pathway, enhancing force transmission in airway smooth muscle and linking this to asthma pathology.

Patterning and folding of intestinal villi by active mesenchymal dewetting

This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.