David O. Holland

This study identifies compound #63 as a potent LZK inhibitor that suppresses tumor growth and enhances EGFR and PI3K pathway blockade in HNSCC and ESCC.

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

The paper quantifies gene and isoform expression changes in metastatic melanoma compared to primary tumors, identifies distinct expression patterns linked to mutational subtypes, and highlights potential therapeutic targets.

The paper quantifies protein stoichiometry in clathrin-mediated endocytosis by integrating copy numbers with interaction networks, revealing trends in sub- and super-stoichiometric proteins and their functional implications.