Danny Leung

Regulatory roles of three-dimensional structures of chromatin domains

The paper investigates how three-dimensional chromatin domain structures influence gene regulation and finds that domain surfaces are enriched for regulatory elements and disease variants.

Epigenomic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potentials

This study identifies epigenetic changes in HCC that affect cis-regulatory elements and retrotransposons, linking them to gene dysregulation and poor prognosis.

SARS-CoV-2 impacts the transcriptome and epigenome at the maternal-fetal interface in pregnancy

The paper investigates how SARS-CoV-2 infection alters the transcriptome and epigenome at the maternal-fetal interface, linking these changes to adverse pregnancy outcomes.

Replication timing maintains the global epigenetic state in human cells.

This study shows that replication timing (RT) is essential for maintaining the global epigenetic state and genome compartmentalization in human cells, with RIF1 playing a central role in this process.