GeneticsPlant Biotechnology JournalPeer-reviewed
Genome-wide analyses of PAM-relaxed Cas9 genome editors reveal substantial off-target effects by ABE8e in rice
Yuechao Wu, Qiurong Ren, Zhaohui Zhong…·Yong Zhang
The paper analyzes off-target effects of PAM-relaxed Cas9 editors in rice using whole-genome sequencing and finds ABE8e causes ~500 A-to-G mutations per plant at TA motifs.
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