Author

Xuelian Zheng

University of Electronic Science and Technology of ChinaORCID 0000-0002-7475-7888Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:plant (other)· 3 Research Focus:variant calling· 3 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Tao ZhangiD· 3 shared Xu Dong TangiD· 3 shared Yiping QiiD· 3 shared Yong ZhangiD· 3 shared Guanqing LiuiD· 2 shared Jianping ZhouiD· 2 shared Qiurong ReniD· 2 shared Yuechao WuiD· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersMolecular Biology

Tao ZhangORCID

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3 papers

Recent·Most cited

High performance TadA-8e derived cytosine and dual base editors with undetectable off-target effects in plants

Tingting Fan, Yanhao Cheng, Yuechao Wu, Shishi Liu, Xu Dong Tang, Yao He, Shanyue Liao, Xuelian Zheng, Tao Zhang, Yiping Qi, Yong Zhang

This study develops and evaluates TadA-8e-derived cytosine and dual base editors in plants, showing high efficiency, purity, and specificity with no off-target effects.

Nature Communications · Jun 14, 2024Peer-reviewedMolecular Biology

Genome-wide analyses of PAM-relaxed Cas9 genome editors reveal substantial off-target effects by ABE8e in rice

Yuechao Wu, Qiurong Ren, Zhaohui Zhong, Guanqing Liu, Yangshuo Han, Yu Bao, Li Liu, Shuyue Xiang, Shuo Liu, Xu Dong Tang, Jianping Zhou, Xuelian Zheng, Simon Sretenovic, Tao Zhang, Yiping Qi, Yong Zhang

The paper analyzes off-target effects of PAM-relaxed Cas9 editors in rice using whole-genome sequencing and finds ABE8e causes ~500 A-to-G mutations per plant at TA motifs.

Plant Biotechnology Journal · May 7, 2022Peer-reviewedGenetics

A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 nucleases in rice

Xu Dong Tang, Guanqing Liu, Jianping Zhou, Qiurong Ren, Qi You, Li Tian, Xuhui Xin, Zhaohui Zhong, Binglin Liu, Xuelian Zheng, Dengwei Zhang, Aimee A. Malzahn, Zhiyun Gong, Yiping Qi, Tao Zhang, Yong Zhang

This study uses whole-genome sequencing to analyze off-target mutations in Cas9 and Cpf1-edited rice, finding most mutations arise from tissue culture rather than nuclease activity.

Genome biology · Jul 4, 2018Peer-reviewedMolecular Biology