Zhe Zhang

This study identifies CCDC113 as a critical protein for stabilizing sperm axoneme and head-tail coupling apparatus, linking its disruption to male infertility.

This study shows that transgene expression in primate liver declines rapidly after initial transduction, even though vector DNA remains in the nucleus, suggesting that genomic integration may be needed for durable expression.

The paper identifies widespread extrachromosomal circular DNA (eccDNA) formation during spermatogenesis and shows microhomology-mediated end joining is the major biogenesis mechanism.