This study identifies CCDC113 as a critical protein for stabilizing sperm axoneme and head-tail coupling apparatus, linking its disruption to male infertility.

eLife · Dec 13, 2024Peer-reviewedDevelopmental Biology

Ancient farmer and steppe pastoralist-related founding lineages contributed to the complex landscape of episodes in the diversification of Chinese paternal lineages

Mengge Wang, Yuguo Huang, Kaijun Liu, Haibing Yuan, Shuhan Duan, Zhiyong Wang, Lan‐Hai Wei, Hongbing Yao, Qiuxia Sun, Jie Zhong, Renkuan Tang, Jing Chen, Yuntao Sun, Xiangping Li, Haoran Su, , Guanglin He

The paper uses ancient DNA and genomic data to trace the genetic contributions of ancient farmer and steppe pastoralist lineages to the paternal genetic diversity of modern Chinese populations.

bioRxiv · Aug 28, 2023 · PreprintGenetics

Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data

Guanglin He, Atif Adnan, Mengge Wang, Wedad Saeed Al-Qahtani, Fatmah Ahmed Safhi, Hui‐Yuan Yeh, Sibte Hadi, Chao Liu, Jun Yao

Frontiers in Ecology and Evolution · Oct 19, 2022Peer-reviewedGenetics

Essential role of CFAP53 in sperm flagellum biogenesis

Bingbing Wu, Xiaochen Yu, Chao Liu, Lina Wang, Tao Huang, Gang Lü, Zi‐Jiang Chen, Wei Li, Hongbin Liu

This study identifies CFAP53 as essential for sperm flagellum biogenesis, showing its role in male infertility and interactions with proteins in the manchette and sperm tail.

Frontiers in Cell and Developmental Biology · May 28, 2021Peer-reviewedDevelopmental Biology