Carlos Omar Oueslati Morales

The paper designs cyclic peptides to inhibit prion conversion in vitro, showing one peptide significantly reduces PrPSc levels by stabilizing PrPc structure.

The paper identifies TFAP2C as a genetic interactor of hnRNP K, showing their roles in mTOR metabolic regulation and a causal link to prion propagation.

The paper identifies BMP signaling as a regulator of prion uptake by screening for genetic modifiers in human cells and shows that modulating BMP components affects prion internalization.

This study shows PKD promotes AMPA receptor endocytosis in hippocampal neurons, affecting synaptic plasticity and network activity.