Giovanni Mariutti

This study identifies PODXL as a suppressor of α-synuclein fibril uptake in neurons, highlighting its glycan-dependent surface properties and interaction with MME.

The paper identifies TFAP2C as a genetic interactor of hnRNP K, showing their roles in mTOR metabolic regulation and a causal link to prion propagation.

The paper identifies BMP signaling as a regulator of prion uptake by screening for genetic modifiers in human cells and shows that modulating BMP components affects prion internalization.

The paper identifies Gpnmb as a marker of a phagocytic microglial state linked to neuronal loss in prion disease, showing its role in clearing apoptotic cells.

This study identifies GLUL upregulation and altered glutamate/glutamine metabolism in prion-infected skeletal muscle, distinct from other neurodegenerative diseases.