Control of Prion Uptake by Bone Morphogenetic Protein Signaling
Elena De Cecco, Giovanni Mariutti, Hasier Eraña, Carlos Omar Oueslati Morales, Davide Caredio, Carolina Appleton, Vangelis Bouris, Stefano Sellitto, Simone Hornemann, Carlo Scialò, Jiang‐An Yin, Enríc Vidal, Magdalini Polymenidou, Joaquín Castilla, Adriano Aguzzi
The paper identifies BMP signaling as a regulator of prion uptake by screening for genetic modifiers in human cells and shows that modulating BMP components affects prion internalization.
bioRxiv · Nov 8, 2025 · PreprintNeuroscience