This study identifies Nlrp6 as a regulator of DNA repair and epithelial regeneration in intestinal crypts, linking DNA damage responses to colorectal cancer progression.

bioRxiv · Mar 2, 2026 · PreprintCell Biology

The E. coli CNF1 toxin induces fetal reprogramming of intestinal stem cells and a serrated colorectal cancer transcriptional signature in organoids

Diane Letourneur, Emma Bergsten, Nathan Raynaud, Juliette Mondy, Giulia Nigro, Landry Laure Tsoumtsa, Amaury Vaysse, Stéphane Descorps‐Declère, Anna E. Yoshida, Caroline Stefani, Iradj Sobhani, Emmanuel Lemichez, Amel Mettouchi

This study shows that the E. coli CNF1 toxin reprograms intestinal stem cells in organoids to a fetal-like state, inducing a serrated colorectal cancer transcriptional signature.

bioRxiv · Oct 2, 2025 · PreprintCancer Biology

Poor prognosis in IBD-complicated colon cancer through gut dysbiosis-related immune response failure

Iradj Sobhani, Nilmara de Oliveira Alves, Mohammad Sadeghi, Cécile Charpy, Emma Bergsten, Aurélien Amiot, Caroline Barau, Francesco Brunetti, Amaury Vaysse, Christophe Tournigand, Mathias Chamaillard, Khashayarsha Khazaie, Denis Mestivier

This study identifies poor prognosis in IBD-related colon cancer due to gut dysbiosis and immune response failure, linked to microbial imbalance and altered gene expression.

bioRxiv · Mar 25, 2025 · PreprintImmunology