Justin Lee Grodin

The paper reports cryo-EM structures of cardiac AL amyloid fibrils from IGLV6 light chains, revealing conserved structural motifs and sequence-dependent folding mechanisms.

The paper detects ATTR aggregates in plasma of polyneuropathic ATTR-V30M amyloidosis patients using a peptide probe and finds no correlation with age or gender.

The paper develops a peptide probe based on cryogenic electron microscopy structures to detect large transthyretin aggregates in ATTR amyloidosis patients' plasma, revealing previously unknown aggregated species.