GeneticsProceedings of the National Academy of SciencesPeer-reviewed
Synthetic hypermutation: gene-drug mutation rate synergy reveals a translesion synthesis mechanism
Romulo Segovia, Yaoqing Shen, Scott A. Lujan…·Peter C. Stirling
The paper quantifies gene-drug interactions in yeast using mutation rate and fitness, identifying synthetic hypermutation cases and revealing a translesion synthesis mechanism.
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