Yaoqing Shen

This study evaluates Parent-of-Origin-Aware genomic analysis (POAga) to improve cascade testing in pancreatic cancer families by clarifying familial risk.

The paper develops EpiSignaLR, a resource for genome-wide episignature analysis using methylation-aware sequencing data, identifying DMRs and classifiers for three neurodevelopmental disorders.

This paper presents a long-read sequencing dataset of cancer samples, showing its ability to resolve structural variants, haplotypes, and methylation patterns in precision medicine.

Copy-scAT deconvolutes single-cell chromatin accessibility to infer genetic subclones in cancer, revealing how genetics influence chromatin profiles and subclonal phenotypes.

This study shows Sgs1 and BLM helicases prevent R-loop induced genome instability in yeast and human cells by reducing R-loop accumulation and mitigating replication-transcription collisions.

The paper quantifies gene-drug interactions in yeast using mutation rate and fitness, identifying synthetic hypermutation cases and revealing a translesion synthesis mechanism.