Author

Romulo Segovia

BC Cancer Agency

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Peter C. StirlingiD· 2 shared Steven J.M. JonesiD· 2 shared Yaoqing SheniD· 2 shared Carolina A. Novoa· 1 shared Christelle Keong· 1 shared Emily Yun-Chia Chang· 1 shared Jean-Yves Masson· 1 shared Maria J. Aristizabal· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Peter C. StirlingORCID

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2 papers

Recent·Most cited

Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop induced genome instability

Carolina A. Novoa, Emily Yun-Chia Chang, Maria J. Aristizabal, Yan Coulombe, Romulo Segovia, Yaoqing Shen, Christelle Keong, Steven J.M. Jones, Jean-Yves Masson, Michael S. Kobor, Peter C. Stirling

This study shows Sgs1 and BLM helicases prevent R-loop induced genome instability in yeast and human cells by reducing R-loop accumulation and mitigating replication-transcription collisions.

bioRxiv · Mar 23, 2017 · PreprintCell Biology

Synthetic hypermutation: gene-drug mutation rate synergy reveals a translesion synthesis mechanism

Romulo Segovia, Yaoqing Shen, Scott A. Lujan, Steven J.M. Jones, Peter C. Stirling

The paper quantifies gene-drug interactions in yeast using mutation rate and fitness, identifying synthetic hypermutation cases and revealing a translesion synthesis mechanism.

Proceedings of the National Academy of Sciences · Feb 21, 2017Peer-reviewedGenetics