Author

Mariana Silva dos Santos

The Francis Crick InstituteORCID 0000-0003-2404-8490Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

James I. MacRaeiD· 3 shared Acely Garza-Garcı́aiD· 1 shared Akhilesh B. ReddyiD· 1 shared Aleksandra Agapova· 1 shared András Dávid NagyiD· 1 shared Angela RodgersiD· 1 shared Antony FearnsiD· 1 shared Beatriz Fuga Rossi TeixeiraiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

James I. MacRaeORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 25, 2025

Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma

Sophie de Carné Trécesson, Philip East, Claire E. Pillsbury…·Julian Downward

This study links oncogenic RAS activity to immune priming and adenosine-driven immune evasion in lung adenocarcinoma, showing both pro-immunogenic and immunosuppressive effects.

DOI 10.1101/2025.11.25.690426

humanbulk RNA-seq

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MicrobiologyNature CommunicationsPeer-reviewedNov 20, 2025

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids

Robert M. Gray, Debbie M. Hunt, Mariana Silva dos Santos…·Luiz Pedro S. de Carvalho

This study shows Mycobacterium tuberculosis remodels its lipidome to survive phosphate starvation by using phosphorus-free lipids and host-derived phosphate sources.

11 citationstop 2%

metabolomicsproteomics

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Systems BiologyMolecular Systems BiologyPeer-reviewedAug 1, 2018

Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations

Guillaume Rey, Nikolay B. Milev, Utham K. Valekunja…·Akhilesh B. Reddy

The paper shows Drosophila S2 cells exhibit daily gene and metabolic oscillations without canonical circadian regulators.

68 citationstop 2%

Drosophilabulk RNA-seq

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