Souvik Ghosal

This paper develops lipid nanoparticles for intracellular antibody delivery, showing efficacy in inhibiting cytosolic targets in cancer and disease models.

The paper identifies a single-subunit oligosaccharyltransferase from Desulfovibrio marinus that enables glycosylation of full-length IgG antibodies in E. coli.

This study develops a method to deliver proteins into cells using ionizable lipid nanoparticles by modifying protein surfaces with an anionic cloak, demonstrating efficacy in cancer cell killing and signaling inhibition.

This study uses lipid nanoparticles to deliver peptide-based degraders, enabling targeted protein degradation in cancer cells and demonstrating reduced target levels in mice.