Author

Daniel L.J. Thorek

Washington University in St. LouisORCID 0000-0003-2437-1239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Pharmacology & Toxicology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:deep learning· 3 Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexander Ridley· 2 shared Bilal Ahmed SiddiquiiD· 2 shared Claire M. StoreyiD· 2 shared Constance YueniD· 2 shared David UlmertiD· 2 shared Diane S. AbouiD· 2 shared Jens Thomas SivekeiD· 2 shared Julie E. ParkiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

Alexander Ridley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pharmacology & ToxicologyProceedings of the National Academy of SciencesPeer-reviewedSep 22, 2026

Key Regulatory Elements of the TGFbeta-LRRC15 Axis Predict Disease Progression and Immunotherapy Resistance Across Cancer Types

Michael Cheng, Claire M. Storey, Mohamed Altai…·David Ulmert

5 citations

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Pharmacology & ToxicologySignal Transduction and Targeted TherapyPeer-reviewedSep 29, 2025

Development of a LRRC15-Targeted Radio-Immunotheranostic Approach to Deplete Pro-tumorigenic Mechanisms and Immunotherapy Resistance

Claire M. Storey, Mohamed Altai, Katharina Lückerath…·David Ulmert

This paper develops a radio-theranostic approach targeting LRRC15 to image and treat cancer, showing tumor reduction and reversal of immunotherapy resistance.

15 citationstop 3%

mouseexperimental assay

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BioengineeringbioRxivPreprintDec 11, 2024

Simulating Alpha Particle Doses at the Micron Scale from Prostate Cancer Patient Derived Bone Metastatic Biopsies Using GATE

Abdulaziz Said, Mahdjoub Hamdi, Isabella Salerno…·Daniel L.J. Thorek

The paper simulates alpha particle doses at the micron scale from prostate cancer bone metastatic biopsies using GATE to evaluate energy and dose distributions in patient-derived specimens.

DOI 10.1101/2024.12.11.627943

humanexperimental assay

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BioinformaticsbioRxivPreprintMar 26, 2023

Interpretable spatial cell learning enhances the characterization of patient tissue microenvironments with highly multiplexed imaging data

Peng Lu, Karolyn A. Oetjen, Stephen T. Oh, Daniel L.J. Thorek

InterSTELLAR improves microenvironment characterization in cancer using multiplexed imaging data by linking tissue subtypes to clinically relevant cell communities.

1 citation

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BioinformaticsNature CommunicationsPeer-reviewedMar 23, 2023

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry

Peng Lu, Karolyn A. Oetjen, Diane E. Bender…·Daniel L.J. Thorek

IMC-Denoise improves Imaging Mass Cytometry image quality by reducing noise and artifacts, enhancing downstream analysis.

68 citationstop 2%

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