This study shows TMAO affects cell type-specific pathways in mouse aorta, promoting atherosclerotic plaque instability by increasing apoptosis and reducing ECM formation.

13 citationstop 4%

mousescRNA-seq

𝕏 PostBluesky

NeuroscienceAdvanced SciencePeer-reviewedMay 28, 2025

Distinguish risk genes functioning at presynaptic or postsynaptic regions and key connectomes associated with pathological α-synuclein spreading

Yuanxi Li, Justin Torok, Shujing Zhang…·Chao Peng

The paper identifies presynaptic and postsynaptic risk genes and key connectomes involved in pathological α-synuclein spreading using mathematical models and gene regulatory network analysis.

5 citations

humanstatistical model

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintMar 11, 2025

Interactions between mild traumatic brain injury and genetics perturb neuronal and glial pathways and networks relevant to learning and memory in ABCD study

Michael Cheng, Melody Mao, Wenjing Meng…·Xia Yang

The paper investigates the interaction between mild traumatic brain injury and genetics to identify pathway and network-level effects on learning and memory in adolescents using the ABCD cohort.

DOI 10.1101/2025.03.11.25323465

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 15, 2022

Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal Cortex

Guanglin Zhang, Graciel Diamante, In Sook Ahn…·Xia Yang

This study shows T4 treatment alters cell-type specific genes, pathways, and networks in hippocampus and frontal cortex after mTBI, reversing mTBI-affected genes and pathways.

DOI 10.1101/2022.11.15.516648

mousescRNA-seq

𝕏 PostBluesky