Zheyao Hu

This study shows c-di-GMP inhibits rRNA methylation by binding to RlmI, modulates ribosome assembly, and promotes antibiotic tolerance in E. coli.

The paper reveals the atomic mechanisms of GDP extraction by SOS1 from KRAS-G12D and KRAS-D12 oncogenes, identifying key residues and interactions involved.

This study uses metadynamics simulations to analyze structural differences between NRAS and its mutations, revealing key dynamic behaviors and potential therapeutic targets.

The paper uses computational simulations to calculate free energy surfaces of benzothiadiazine derivatives in aqueous solution, identifying stable conformations and transition states.

This paper describes the design of a lipid-based drug, LIG1, that targets KRAS4B-G12D and phosphodiesterase-delta to inhibit cancer cell proliferation.