Author

Megan K. Le

MIT Computer Science and Artificial Intelligence LaboratoryORCID 0000-0003-2442-7212Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Assay:long-read sequencing· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Andrew Rhiner· 1 shared Ayesha RahmaniD· 1 shared Bennett Van HouteniD· 1 shared Dmitri V. FilippoviD· 1 shared Elizabeth G. Blade· 1 shared Frederick Kumi-AnsahiD· 1 shared Gerbrand J. van der Heden van NoortiD· 1 shared Heng LiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Andrew Rhiner

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 9, 2026

PARP1 recruits SPRTN to DNA-protein crosslinks through a conserved poly-ADP-ribose binding domain.

Katelyn Hurley, Liam P. Leary, Martin Garcia…·Jaime López-Mosqueda

This study identifies PARP1's role in recruiting SPRTN to DPCs via PARylation, revealing a mechanism for DPC repair and degradation.

1 citation

statistical modelexperimental assay

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BioinformaticsbioRxivPreprintJul 29, 2024

Long-range somatic structural variation calling from matched tumor-normal co-assembly graphs

Megan K. Le, Qian Qin, Heng Li

This paper introduces colorSV, a method for calling long-range somatic structural variants using co-assembly graphs, achieving high precision and sensitivity in translocation detection.

3 citations

humanlong-read sequencing

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