Dmitri V. Filippov

This study identifies two novel biosynthetic intermediates and characterizes their enzymes in the unique glycan modification pathway of C. difficile flagellin.

This study identifies PARP1's role in recruiting SPRTN to DPCs via PARylation, revealing a mechanism for DPC repair and degradation.

The paper identifies PARP7 as an enzyme that ADP-ribosylates the androgen receptor, marking it for degradation and creating negative feedback on AR-dependent gene expression.

This paper presents a cryo-ET structure of CRP bound to C1 complex and PC ligands, revealing how CRP activates complement and identifies residues for therapeutic targeting.