Gerbrand J. van der Heden van Noort

The paper identifies UFMylation as an antibacterial pathway using proximity biotinylation and mass spectrometry, showing it targets intracellular Shigella and Salmonella.

This study uses protein semi-synthesis and voltage-clamp fluorometry to track real-time conformational changes in the cardiac sodium channel NaV1.5 during inactivation.

This study investigates the role of USP8 in B-cell development and multiple myeloma, showing its impact on proteostasis and identifying potential therapeutic strategies.

This study identifies PARP1's role in recruiting SPRTN to DPCs via PARylation, revealing a mechanism for DPC repair and degradation.

The paper identifies RNF114 as a specific reader of ubiquitinated ADP-ribose using a chemoproteomics approach and validates its interaction with the modified molecule.

The paper develops a mass spectrometry-based assay to screen E2/E3 ligase pairs for their ability to form ubiquitin chains and analyze chain types.

The paper identifies a new E2 ubiquitin-conjugating enzyme in Plasmodium falciparum using a ubiquitin-activity based probe and validates its function through structural and biochemical analysis.

The paper develops covalent probes to target Legionella pneumophila effector enzymes, demonstrating their effectiveness in capturing DupA through in vitro testing and structural analysis.

The paper identifies two novel Legionella OTU-like deubiquitinases, LotB and LotC, and describes their structural and functional differences in ubiquitin chain cleavage during infection.