Author

Sachet Ashok Shukla

Broad InstituteORCID 0000-0003-2445-3584Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Catherine J. WuiD· 2 shared Alexander FilatenkoviD· 1 shared Alexander GuseviD· 1 shared Alexandra–Chloé VillaniiD· 1 shared Amin H. NassariD· 1 shared Andrew Lachlan SchmidtiD· 1 shared Biagio RicciutiiD· 1 shared Bijal Thakkar· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Catherine J. WuORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 29, 2025

ASXL1 truncating mutations drive leukemic resistance to T cell attack

Dustin McCurry, Zhongqi Ge, Jaehyun Lee…·Pavan Bachireddy

This study identifies ASXL1 truncating mutations as a driver of leukemic resistance to T cell attack and proposes EZH2 inhibition as a therapeutic strategy to overcome this resistance.

DOI 10.1101/2025.05.29.656798

humanwhole-exome sequencing

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Genetic & Genomic MedicinemedRxivPreprintApr 10, 2022

Germline variants associated with immunotherapy-related adverse events

Stefan Groha, Sarah Abou Alaiwi, Wenxin Vincent Xu…·Alexander Gusev

This study identifies three germline variants associated with immune-related adverse events in patients treated with immune checkpoint inhibitors.

DOI 10.1101/2022.04.10.22273627

humanGWAS summary statistics

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BioinformaticsbioRxivPreprintNov 1, 2018

The landscape of antigen-specific T cells in human cancers

Bo Li, Longchao Liu, Jian Zhang…·Yang‐Xin Fu

The paper identifies cancer-associated T cells using TCR repertoire and gene expression data, revealing novel regulators and antigens with potential for immune monitoring and immunotherapy.

3 citations

humanscRNA-seq

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