ASXL1 truncating mutations drive leukemic resistance to T cell attack
Dustin McCurry, Zhongqi Ge, Jaehyun Lee, Rishi Pasumarthi, Xiaohong Leng, Thomas Köhnke, Oren Pasvolsky, Pranaya Raparla, Vinhkhang N. Nguyen, Katie Maurer, Shuqiang Li, Kenneth J. Livak, Emerie E Danson, Bijal Thakkar, Elham Azizi, , Pavan Bachireddy
This study identifies ASXL1 truncating mutations as a driver of leukemic resistance to T cell attack and proposes EZH2 inhibition as a therapeutic strategy to overcome this resistance.
bioRxiv · May 29, 2025 · PreprintCancer Biology