Author

Joseph C. Boktor

California Institute of TechnologyORCID 0000-0003-2456-1913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Sarkis K. MazmanianiD· 2 shared Alexander Viloria WinnettiD· 1 shared Anastasiya D. OguienkoiD· 1 shared Anastasiya MoiseyenkoiD· 1 shared Aubrey M SchonhoffiD· 1 shared Blake DirksiD· 1 shared Dorsa Daeizadeh· 1 shared Giacomo AntonelloiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Sarkis K. MazmanianORCID

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2 papers

Recent·Most cited

Physiologynpj Parkinson s DiseasePeer-reviewedMar 5, 2026

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Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice

Anastasiya Moiseyenko, Giacomo Antonello, Aubrey M Schonhoff…·Sarkis K. Mazmanian

Oral Faecalibacterium prausnitzii, the taxon most consistently depleted in PD stool, improved motor and GI deficits and lowered α-synuclein aggregates in male Thy1-ASO mice.

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mousebulk RNA-seq

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Physiologynpj Parkinson s DiseasePeer-reviewedOct 30, 2024

α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice

Lívia H. Morais, Joseph C. Boktor, Siamak MahmoudianDehkordi…·Sarkis K. Mazmanian

This study shows that α-synuclein overexpression and the microbiome alter the gut and brain metabolome in mice, with TMAO levels correlating across tissues and linking to PD-like outcomes.

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mousemetabolomics

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