Sarkis K. Mazmanian

The paper develops SPARTA for in situ genetic reprogramming of native microbiomes and introduces ScRibe-seq to identify engineered taxa, demonstrating functionality across diverse environments.

The paper identifies AAV vectors that efficiently deliver transgenes to the nervous systems of spiny mice, enabling functional studies of regeneration.

Oral Faecalibacterium prausnitzii, the taxon most consistently depleted in PD stool, improved motor and GI deficits and lowered α-synuclein aggregates in male Thy1-ASO mice.

The paper introduces microbiomeMASST, a metadata network graph linking metabolites across datasets, enabling cross-study analysis of microbial metabolites and their biological context.

This study shows that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain of a Parkinson's disease mouse model, worsening motor symptoms.

This study shows that the microbiome influences immune responses and cognitive deficits in sex-specific ways in mouse models of Alzheimer's disease.

The paper presents a multi-organ metabolomics atlas in AD mouse models, identifying dysregulated metabolites and microbiome associations linked to oxidative stress and cognitive impairment.

This study shows that α-synuclein overexpression and the microbiome alter the gut and brain metabolome in mice, with TMAO levels correlating across tissues and linking to PD-like outcomes.