Céline Verheggen

The paper identifies RPAP3 and PIH1D1 as R2TP subunits and shows their role in assembling INO80, SRCAP, and TIP60 complexes through physical interactions and functional validation.

This paper identifies a novel role for the R2T complex in early box H/ACA snoRNP maturation by characterizing interactions between SHQ1, RuvBL1:RuvBL2, and other factors.

The paper identifies co-translational interactions between R2TP and client proteins, revealing a mechanism called co-translational chaperone channeling that facilitates early assembly of protein complexes.

This study investigates the 3D structure and function of the human R2SP complex using biochemical and structural methods, revealing similarities to the canonical R2TP complex and differences in ATPase activity and adaptor binding.

The paper identifies the RPAP3-TRBP interaction and shows the HSP90/R2TP chaperone complex's role in dsRNA pathways by binding TRBP and affecting AGO and Dicer function.

This study investigates the role of the R2TP chaperone in intestinal stem and progenitor cells, showing its critical function in proliferation and its association with poor colorectal cancer prognosis.