Author

Paulo E. Santo

Centre National de la Recherche ScientifiqueORCID 0000-0003-4277-3573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Célia Plisson‐ChastangiD· 3 shared Ana C. F. PaivaiD· 2 shared Céline VerheggeniD· 2 shared Édouard BertrandiD· 2 shared Hugo Gizardin-FredoniD· 2 shared Laura PlassartiD· 2 shared Marie-Eve ChagotiD· 2 shared Pedro M. F. SousaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

Célia Plisson‐ChastangORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintJun 2, 2026

The R2T(P) complex orchestrates the SHQ1 driven early steps of box H/ACA snoRNP maturation

Philipp Busse, Ana C. F. Paiva, Paulo E. Santo…·Tiago M. Bandeiras

This paper identifies a novel role for the R2T complex in early box H/ACA snoRNP maturation by characterizing interactions between SHQ1, RuvBL1:RuvBL2, and other factors.

DOI 10.64898/2026.05.30.726169

protein structureprotein sequence

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Molecular BiologyHemaSpherePeer-reviewedJun 1, 2026

Translatome and translation dynamics analysis of a RiboCancer cell line panel reveals that leukemia-associated Rps15 mutations rewire translation through codon-specific tRNA accommodation defects.

Anaïs Astier, Marino Caruso, Stijn Vereecke…·Kim De Keersmaecker

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

2 citations

humanRibo-seq

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BiophysicsbioRxivPreprintJan 27, 2025

R2TP-like Quaternary Chaperones: a comprehensive overview to understand the dynamic R2SP complex

Paulo E. Santo, Marie-Eve Chagot, Hugo Gizardin-Fredon…·Xavier Manival

This study investigates the 3D structure and function of the human R2SP complex using biochemical and structural methods, revealing similarities to the canonical R2TP complex and differences in ATPase activity and adaptor binding.

1 citation

humanstructural biology

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