Author

Laurence Decourty

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 4 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

Cosmin SaveanuiD· 4 shared Abdelkader NamaneiD· 2 shared Alain JacquieriD· 2 shared Ana C. F. PaivaiD· 1 shared Camille BellièresiD· 1 shared Caroline Proux· 1 shared Céline VerheggeniD· 1 shared Christophe MalabatiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMolecular Biology

Cosmin SaveanuORCID

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Author profile →

4 papers

Recent·Most cited

A large-scale analysis of the R2TP chaperone network reveals its contribution to the assembly of INO80, SRCAP and TIP60

Yoann Abel, Manon Philippe, Laurence Decourty, Ana C. F. Paiva, Philipp Busse, Marie-Cécile Robert, Serge Urbach, Camille Bellières, Franck Vandermoere, Jacques Imbert, Martial Sevéno, Cosmin Saveanu, Pedro M. F. Sousa, Séverine Boulon, Tiago M. Bandeiras, , Céline Verheggen

The paper identifies RPAP3 and PIH1D1 as R2TP subunits and shows their role in assembling INO80, SRCAP, and TIP60 complexes through physical interactions and functional validation.

bioRxiv · Jul 8, 2026 · PreprintMolecular Biology

Deadenylation rate is not a major determinant of RNA degradation in yeast

Léna Audebert, Frank Feuerbach, Laurence Decourty, Abdelkader Namane, Emmanuelle Permal, Gwenaël Badis, Cosmin Saveanu

The paper shows that mRNA stability in yeast is determined by decapping speed, not deadenylation rate, with unstable mRNAs having rapid decapping and longer poly(A) tails.

bioRxiv · Jan 16, 2023 · PreprintMolecular Biology

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

Laurence Decourty, Christophe Malabat, Emmanuel Frachon, Alain Jacquier, Cosmin Saveanu

The paper performs large-scale genetic interaction screens in yeast to study RNA metabolism, identifying gene links to biological processes and validating a specific connection to mRNA translation initiation.

Nucleic Acids Research · Aug 2, 2021Peer-reviewedGenetics

Detection and Degradation of Nonsense-mediated mRNA Decay Substrates Involve Two Distinct Upf1-bound Complexes

Marine Dehecq, Laurence Decourty, Abdelkader Namane, Caroline Proux, Joanne Kanaan, Hervé Le Hir, Alain Jacquier, Cosmin Saveanu

The paper identifies two distinct Upf1-bound complexes in yeast NMD, Detector and Effector, and shows their roles in substrate detection and degradation.

bioRxiv · Feb 16, 2018 · PreprintMolecular Biology