Systems BiologybioRxivPreprint
Transcriptional reprogramming by IL-2 variant generates metabolically active stem-like T cells
Yaquelin Ortiz-Miranda, María Masid, Cristina Jiménez‐Luna…·George Coukos
This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.
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