Author

Helen Carrasco Hope

Centre Hospitalier Universitaire VaudoisORCID 0000-0001-5583-4510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Bili SeijoiD· 1 shared Cristina Jiménez‐LunaiD· 1 shared David WrightiD· 1 shared Elisabetta CribioliiD· 1 shared Galia MontalvoiD· 1 shared George CoukosiD· 1 shared Graham P. CookiD· 1 shared Isaac CrespoiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSystems Biology

Bili SeijoORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 9, 2025

Phospho-enol pyruvate carboxykinase inhibition limits inflammatory T cell activation

Rebecca J. Brownlie, Helen Carrasco Hope, David Wright…·Robert J. Salmond

This study shows that PEPCK-M is upregulated in T cells during activation and that its inhibition reduces T cell effector functions and cytokine production.

DOI 10.1101/2025.09.09.675120

humanproteomics

𝕏 PostBluesky

Systems BiologybioRxivPreprintMay 24, 2023

Transcriptional reprogramming by IL-2 variant generates metabolically active stem-like T cells

Yaquelin Ortiz-Miranda, María Masid, Cristina Jiménez‐Luna…·George Coukos

This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky