Author

Isaac Crespo

Centre Hospitalier Universitaire VaudoisORCID 0000-0003-3151-3901Unclaimed ORCID profile · follow to get notified of new preprints

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Isaac Crespo1 paper

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Amel BekkariD· 1 shared Angélique PaboisiD· 1 shared Bili SeijoiD· 1 shared Cristina Jiménez‐LunaiD· 1 shared Elisabetta CribioliiD· 1 shared Galia MontalvoiD· 1 shared George CoukosiD· 1 shared Helen Carrasco HopeiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSystems Biology

Amel BekkarORCID

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2 papers

Recent·Most cited

A combined computational and experimental approach to successfully predict the behavior of metastatic tumor-associated macrophages in humanbreast cancer

Amel Bekkar, Angélique Pabois, Isaac Crespo, Riccardo Turrini, Ioannis Xénarios, Marie‐Agnès Doucey

The paper identifies pro-metastatic TAMs in breast cancer and develops a computational-experimental framework to predict and inhibit their activity through pathway analysis and drug screening.

bioRxiv · Feb 6, 2025 · PreprintSystems Biology

Transcriptional reprogramming by IL-2 variant generates metabolically active stem-like T cells

Yaquelin Ortiz-Miranda, María Masid, Cristina Jiménez‐Luna, Galia Montalvo, Tania Muller, Nicolas Rayroux, Elisabetta Cribioli, Jesús Corría-Osorio, Helen Carrasco Hope, Romain Vuillefroy de Silly, Bili Seijo, Pierpaolo Ginefra, Kalet León, Nicola Vannini, Ping‐Chih Ho, , George Coukos

This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.

bioRxiv · May 24, 2023 · PreprintSystems Biology