Author

Yaquelin Ortiz-Miranda

Center of Molecular Immunology (Cuba)ORCID 0000-0002-9136-6205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

George CoukosiD· 2 shared María MasidiD· 2 shared Nicola VanniniiD· 2 shared Pierpaolo GinefraiD· 2 shared Vassily Hatzimanikatis AiD· 2 shared Bili SeijoiD· 1 shared Cristina Jiménez‐LunaiD· 1 shared David BarrasiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersSystems Biology

George CoukosORCID

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2 papers

Recent·Most cited

Computational Inference of Metabolic Programs: A Case Study Analyzing the Effect of BRCA1 Loss

María Masid, Ioanna A. Rota, David Barras, Flavia De Carlo, Pierpaolo Ginefra, Mathieu Desbuisson, Yaquelin Ortiz-Miranda, Dmitriy Zamarin, Sohrab P. Shah, Nicola Vannini, George Coukos, Denarda Dangaj Laniti, Vassily Hatzimanikatis A

This study introduces iMSEA, a computational framework that identifies metabolic state shifts in BRCA1-deficient cancers using omics data and validates findings with experimental assays.

bioRxiv · Nov 18, 2025 · PreprintSystems Biology

Transcriptional reprogramming by IL-2 variant generates metabolically active stem-like T cells

Yaquelin Ortiz-Miranda, María Masid, Cristina Jiménez‐Luna, Galia Montalvo, Tania Muller, Nicolas Rayroux, Elisabetta Cribioli, Jesús Corría-Osorio, Helen Carrasco Hope, Romain Vuillefroy de Silly, Bili Seijo, Pierpaolo Ginefra, Kalet León, Nicola Vannini, Ping‐Chih Ho, , George Coukos

This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.

bioRxiv · May 24, 2023 · PreprintSystems Biology