Ulrich auf dem Keller

This study identifies RHBDL2 as a calcium-activated rhomboid protease that suppresses EGFR signaling in keratinocytes by shedding its ectodomain, thereby limiting cell migration and invasion.

This study identifies and analyzes tissue-specific protease dynamics in the pig respiratory tract during influenza A virus infection, revealing distinct protease activity patterns and their roles in antiviral responses and pathogenesis.

This study shows that increased meprin α expression in mice leads to a psoriasis-like skin phenotype through degradation of dermokine, promoting hyperproliferation and inflammation.

The paper shows that persistent ECM scarring in the colon reprograms intestinal stem cells to drive chronic inflammation through a modECM niche.

InstaNovo is a transformer model for de novo peptide sequencing that outperforms existing methods, enabling accurate identification of peptides and discovery of novel sequences and organisms.

The paper investigates dermokine's role in keratinocyte adhesion through multi-omics analysis, showing that dermokine loss increases p120 phosphorylation and reduces cell-cell adhesion.

CLIPPER 2.0 is a computational tool for peptide-level annotation and analysis of positional proteomics data, demonstrating its use on GluC and MMP9 cleavage in HeLa lysates.

This study compares three protein structure prediction tools on snake venom toxins with no reference templates, finding AlphaFold2 performs best, while ColabFold is computationally less intensive.

The paper evaluates the impact of different trypsin variants on proteomics experiments across multiple sample types and methods, identifying variations in performance and providing handling recommendations.

The paper develops a tailored DIA method for single-cell proteomics to improve quantification from low-input samples and establishes a complete scp-MS workflow.

The paper presents a workflow for single-cell proteomics to study cellular heterogeneity in leukemia, demonstrating the ability to quantify thousands of proteins per cell.

The paper identifies a pre-symptomatic extracellular-matrix signature in colitis models and validates it in human subjects, showing its mediation by neutrophils and monocytes.

This study shows that tendon tissue response to mechanical unloading depends on the simulated physiological niche, with oxidative stress driving proteolytic matrix breakdown.