Author

Maximilien Grandclaudon

InsermORCID 0000-0003-2494-6223Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Vassili SoumelisiD· 3 shared Agnes KnopfiD· 1 shared Alexandra HardyiD· 1 shared Alexandre GrimaldiiD· 1 shared Andrew J. PierceiD· 1 shared Anna ThalleriD· 1 shared Antonio CappuccioiD· 1 shared Aurélien NaldiiD· 1 shared

Activity by Year

2015-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersSystems Biology

Vassili SoumelisORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintFeb 10, 2026

OKN4395, a first-in-class EP2/EP4/DP1 triple antagonist reprograms prostanoid-driven immunosuppression to restore antitumor immunity

Maximilien Grandclaudon, Morgane Boulch, Anna Thaller…·Andrew J. Pierce

OKN4395, a triple EP2/EP4/DP1 antagonist, restores antitumor immunity by reversing prostanoid-driven immunosuppression and synergizes with anti-PD1 therapy.

DOI 10.64898/2026.02.08.704632

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Systems BiologyNature CommunicationsPeer-reviewedFeb 17, 2021

ICELLNET: a transcriptome-based framework to dissect intercellular communication

Floriane Noël, Lucile Massenet-Regad, Irit Carmi-Levy…·Vassili Soumelis

ICELLNET integrates ligand-receptor interactions and communication scores to analyze cell-to-cell communication in transcriptomic data, revealing novel interactions in breast cancer and dendritic cells.

209 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

Systems BiologyFrontiers in Bioengineering and BiotechnologyPeer-reviewedJan 28, 2015

Model checking to assess T-helper cell plasticity

Wassim Abou-Jaoudé, Pedro Monteiro, Aurélien Naldi…·Denis Thieffry

The paper uses symbolic model checking to analyze T-helper cell plasticity by examining attractor switches in a logical model of their differentiation network.

DOI 10.3389/fbioe.2014.00086

statistical modelcell type annotation

𝕏 PostBluesky