Simon D. Connell

This study modifies the membranolytic peptide MP1 with EGFR-binding and MMP-2 cleavage sequences to target cancer cells, showing reduced toxicity and tumor growth in vivo.

The paper identifies MP-1 peptide mutants with enhanced selectivity for cancer-like membranes and breast cancer cells, revealing structure-activity relationships through model membranes and cell assays.

The paper investigates fluorescence quenching in lipid bilayers using FLIM and finds varying quenching behavior among fluorophores, supporting a transfer-to-trap mechanism with concentration-dependent trap formation.