Author

Andrew Booth

University of Leeds

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Paul A. BealesiD· 3 shared Arindam PramanikiD· 2 shared Dagmara KobzaiD· 2 shared Simon D. ConnelliD· 2 shared Thomas A. HughesiD· 2 shared William J. BrackenburyiD· 2 shared Barbara CianiiD· 1 shared Christopher J. Marklew· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Paul A. BealesORCID

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3 papers

Recent·Most cited

EGFR-targeted and MMP-activated membranolytic peptides derived from Polybia paulista MP1 kill cancer cells specifically in vitro and reduce tumour growth in vivo

Arindam Pramanik, Andrew Booth, Dagmara Kobza, William J. Brackenbury, Simon D. Connell, Paul A. Beales, Thomas A. Hughes

This study modifies the membranolytic peptide MP1 with EGFR-binding and MMP-2 cleavage sequences to target cancer cells, showing reduced toxicity and tumor growth in vivo.

bioRxiv · Oct 7, 2025 · PreprintCancer Biology

Determinants of membrane sensitivity to the peptide MP-1 (Polybia paulista)

Andrew Booth, Arindam Pramanik, Dagmara Kobza, Didi Derks, Lekshmi Kailas, William J. Brackenbury, Simon D. Connell, Thomas A. Hughes, Paul A. Beales

The paper identifies MP-1 peptide mutants with enhanced selectivity for cancer-like membranes and breast cancer cells, revealing structure-activity relationships through model membranes and cell assays.

bioRxiv · Sep 17, 2025 · PreprintBiophysics

In vitro membrane remodelling by ESCRT-II/ESCRT-III is regulated by negative feedback from membrane tension

Andrew Booth, Christopher J. Marklew, Barbara Ciani, Paul A. Beales

The paper demonstrates that membrane tension, regulated by ILV formation, negatively feedbacks to control ESCRT-III activity in vitro, with potential implications for in vivo functions.

iScience · Apr 20, 2019Peer-reviewedSynthetic Biology