Author

Matthew K. Siggins

University of SurreyORCID 0000-0003-2504-6518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

Kristin K. HuseiD· 2 shared Shiranee SriskandaniD· 2 shared Antonio Di MaioiD· 1 shared Claire E. TurneriD· 1 shared David G. JacksoniD· 1 shared Elita JauneikaiteiD· 1 shared Ho Kwong LiiD· 1 shared Lucy LambiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Kristin K. HuseORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintFeb 11, 2026

M1 protein expression determines niche-specific spread of Streptococcus pyogenes

Kristin K. Huse, Elita Jauneikaite, Nicola N. Lynskey…·Shiranee Sriskandan

This study shows that secreted M protein, not cell-surface M protein, is critical for lymphatic survival and systemic infection of Streptococcus pyogenes in mice.

DOI 10.64898/2026.02.11.705257

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintApr 21, 2025

Lymphatic dissemination is a major route of systemic invasion by diverse extracellular bacteria in soft tissue infection

Matthew K. Siggins, Ho Kwong Li, Kristin K. Huse…·Shiranee Sriskandan

This study shows that lymphatic dissemination through sequential lymph nodes is a major route for systemic spread of extracellular bacteria in soft tissue infections.

DOI 10.1101/2025.04.21.649860

mouseexperimental assay

𝕏 PostBluesky